The role of fibromodulin in inflammatory responses and diseases associated with inflammation

Inflammation is an immune response that the host organism eliminates threats from foreign objects or endogenous signals. It plays a key role in progression, prognosis as well therapy of diseases. Chronic inflammatory diseases have been regarded main cause death worldwide at present, which greatly affect vast number individuals, producing economic and social burdens. Thus, developing drugs targeting inflammation has become necessary attractive world. Currently, accumulating evidence suggests small leucine-rich proteoglycans (SLRPs) exhibit essential roles various responses by acting anti-inflammatory pro-inflammatory different scenarios Of particular interest was well-studied member, termed fibromodulin (FMOD), largely explored inflammatory-related In this review, focus given to FMOD including relationship with complement system cells, associated inflammation, such skin wounding healing, osteoarthritis (OA), tendinopathy, atherosclerosis, heart failure (HF). By conducting we intend gain insight into may open way for development new anti-inflammation